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Back to the Biology: Precision Meets Progress in Immunotherapy
Bi & Multispecific Engineering
Nanobody applications to bi and multispecifics
Creating functional bispecifics and multispecifics
Target selection
Engineering bi/multispecifics for solid tumors
Translating Multispecific Success
Combining multispecifics with cellular modalities
ML and data in bi/multispecific development
Addressing safety and regulatory hurdles
Learnings from solid tumor clinical successes
Antibody-Drug Conjugates
Improvements in linker technologies
Site-specific conjugation
Addressing resistance and toxicity to improve therapeutic indexes
Enhancing solid tumor targeting and specificity for better efficacy
Breakthroughs in Cell Therapy
CAR T therapy
TILs, TCRs, Tregs for solid tumor indications
Combining multiple cell therapies together
Lowering attrition rate in the clinic
Autoimmunity
Learnings from IO applied to autoimmunity
B cell targeting
Understanding the autoimmunity microenvironment
Transient approaches
Innate Immunity
Understanding solid tumor biology
NK cell engagers and gamma delta developments
ML and data science applications
Translatable models
